Enhanced hyperpolarized chemical shift imaging based on a priori segmented information

Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging.

Hyperpolarized 13C offers high signal-to-noise ratios for imaging metabolic activity in vivo, but care must be taken when designing pulse sequences because the magnetization cannot be recovered once it has decayed. It has a short lifetime, on the order of minutes, and gets used up by each RF excitation. In this paper, we present a new dynamic chemical-shift imaging method that uses specialized ...

Double Spin-Echo Spiral Chemical Shift Imaging for Rapid Metabolic Imaging of Hyperpolarized [1-C]-Pyruvate

Introduction Rapid chemical shift imaging (CSI) techniques are of considerable interest for hyperpolarized C metabolic imaging [1,2]. Undersampled spiral CSI (spCSI) using a free induction decay (FID) acquisition mode has been applied to real-time metabolic imaging with acquisition times of less than 1 s per slice [3]. The FID acquisition necessitates phase correction during reconstruction for ...

Echo Planar Spectroscopic Imaging of Hyperpolarized 13C in a Clinical System with Reduced Chemical Shift Artifacts

Single-Shot Spiral Chemical Shift Imaging in the Rat In Vivo with Hyperpolarized [1-C]-Pyruvate

shot spCSI in 125 ms. Color scale is the same for all images (with Pyr scaled down by 2.5), threshold at 15% of maximum. (b) Same as (a), but acquired with FIDCSI (Tacq = 24 s). Fig. 2: Time courses of the average signal intensity from ROIs in the left kidney (solid) and heart (dashed) for Pyr (blue circle), Lac (red square), and Ala (green cross). The time courses for Pyr are scaled down by a ...

Echoplanar chemical shift imaging.

A novel method of chemical shift imaging utilizing echoplanar imaging (EPI) has been developed for the purpose of improving the spatial resolution of metabolite images for the specific goal of high spatial resolution mapping of neuronal content. An EPI sequence was modified to allow temporal offsets of the 180 degree refocusing pulse that encode the chemical shift information into the phase of ...